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    fbxw8 F-box and WD repeat domain containing 8 [ Danio rerio (zebrafish) ]

    Gene ID: 100136859, updated on 27-Mar-2024

    Summary

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    Official Symbol
    fbxw8provided by ZNC
    Official Full Name
    F-box and WD repeat domain containing 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-111
    See related
    Ensembl:ENSDARG00000079089 AllianceGenome:ZFIN:ZDB-GENE-080204-111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:172294
    Summary
    Predicted to be part of preribosome, large subunit precursor. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (11864308..11906411, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (11364208..11405703, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor a Neighboring gene F-box protein 21 Neighboring gene tescalcin a Neighboring gene uncharacterized LOC101884919 Neighboring gene ring finger protein, transmembrane 2 Neighboring gene SREBF pathway regulator in golgi 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box/WD repeat-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114578.1 → NP_001108050.1  F-box/WD repeat-containing protein 8

      See identical proteins and their annotated locations for NP_001108050.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155644
      UniProtKB/TrEMBL
      A9JRF9
      Related
      ENSDARP00000101492.2, ENSDART00000114378.4
      Conserved Domains (4) summary
      COG2319
      Location:300 → 626
      WD40; WD40 repeat [General function prediction only]
      pfam12937
      Location:138 → 182
      F-box-like; F-box-like
      sd00039
      Location:411 → 454
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:221 → 525
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      11864308..11906411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021475977.1 → XP_021331652.1  F-box/WD repeat-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PJL4
      Conserved Domains (3) summary
      sd00039
      Location:234 → 273
      7WD40; WD40 repeat [structural motif]
      pfam12937
      Location:138 → 180
      F-box-like
      cl25539
      Location:221 → 479
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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